Select Microorganism Type

Penicillium pinophilum LT4

CRA-CAT2938

Generality
Isolated by Rosario Nicoletti 
Identified by Fabrizio Marziano 
Year 1997 
State Italy 
Region (regione) Apulia 
District (provincia) Lecce 
Place of maintenance Unità di Ricerca per le Colture alternative al Tabacco
Isolated from Soil 
Mainteinance Method
Mainteinance Method
Subculturing2
Growing medium PDA 
Year 2009 
N° of replicate maintained 10 
References
References
32. De Stefano S, Nicoletti R, Milone A, Zambardino S, 1999. 3-O-Methylfunicone, a fungitoxic metabolite produced by the fungus Penicillium pinophilum. Phytochemistry 52, 1399-1401 
49. Stammati A, Nicoletti R, De Stefano S, Zampaglioni F, Zucco F, 2002. A novel cytostatic compound derived from the fungus Penicillium pinophilum: an in vitro study. Alternatives to Laboratory Animals 30, 69-75 
Nicoletti R, Carella A, 2004. Composti a scheletro funiconico prodotti da specie di Penicillium. Petria 14, 1-11 
Nicoletti R, Buommino E, De Stefano M, Tufano MA, 2004. Biological activities of 3-O-methylfunicone, a secondary metabolite of Penicillium pinophilum. Proceedings of the 7th Conference of the European Foundation for Plant Pathology, Aberdeen, United Kingdom, 5-10 September 2004, 69 
Buommino E, Nicoletti R, Gaeta GM, Orlando M, Ciavatta ML, Baroni A, Tufano MA, 2004. 3-O-Methylfunicone, a secondary metabolite produced by Penicillium pinophilum, induces growth arrest and apoptosis in HeLa cells. Cell Proliferation 37, 413-426 
Nicoletti R, De Stefano M, De Stefano S, Trincone A, Marziano F, 2004. Antagonism against Rhizoctonia solani and fungitoxic metabolite production by some Penicillium isolates. Mycopathologia 158, 465-474 
Nicoletti R, Buommino E, De Filippis A, Carella A, Baroni A, Tufano MA, 2005. New antitumor drugs from Penicillium species. Proceedings of COHAB 2005 - Conference on Health and Biodiversity, Galway, Ireland, 23-25 August 2005, 80 
Nicoletti R, De Stefano M, Carella A, 2006. Mycoparasitism of Penicillium pinophilum toward Rhizoctonia solani. Abstract book of the 8th Conference of the European Foundation for Plant Pathology, Frederiksberg, Denmark, 13-17 August 2006, 107 
Buommino E, Boccellino M, De Filippis A, Petrazzuolo M, Cozza V, Nicoletti R, Ciavatta ML, Quagliuolo L, Tufano MA, 2007. 3-O-methylfunicone produced by Penicillium pinophilum affects cell motility of breast cancer cells, downregulating ?v?5 integrin and inhibiting metalloproteinase-9 secretion. Molecular Carcinogenesis 46, 930-940 
Nicoletti R, Buommino E, De Filippis A, Lopez-Gresa MP, Manzo E, Carella A, Petrazzuolo M, Tufano MA, 2008. Bioprospecting for antagonistic Penicillium strains as a resource of new antitumor compounds. World Journal of Microbiology and Biotechnology 24, 189-195 
Nicoletti R, Ciavatta ML, Buommino E, Tufano MA, 2008. Antitumor extrolites produced by Penicillium species. International Journal of Biomedical and Pharmaceutical Sciences 2, 1-23 
Buommino E, De Filippis A, Petrazzuolo M, Nicoletti R, Baroni A, Tufano MA, 2008. 3-O-methylfunicone, a metabolite from Penicillium pinophilum, inhibits proliferation of human tumoral cells by inducing apoptosis. Book of Abstracts of the PSE Symposium on Natural Products in Cancer Therapy, Napoli, Italy, 23-26 September 2008, P5 
Nicoletti R, De Stefano M, Buommino E, Ciavatta ML, Tufano MA, 2008. 3-O-Methylfunicone, a fungitoxic and antitumor extrolite produced by Penicillium pinophilum. Abstract Book of the International Conference ‘Ehrlich II’, Nürnberg, Germany, 3-5 October 2008, 229 
Nicoletti R, Manzo E, Ciavatta ML, 2009. Occurrence and bioactivities of funicone-related compounds. International Journal of Molecular Sciences 10, 1430-1444 
Baroni A, De Luca A, De Filippis A, Petrazzuolo M, Manente L, Nicoletti R, Tufano MA, Buommino E, 2009. 3-O-Methylfunicone, a metabolite from Penicillium pinophilum, inhibits proliferation of human melanoma cells by causing G2/M arrest and inducing apoptosis. Cell Proliferation 42, 541-553 
Buommino E, Paoletti I, De Filippis A, Nicoletti R, Ciavatta ML, Menegozzo S, Menegozzo M, Tufano MA, 2009. 3-O-Methylfunicone modulates ERK1/2 activity by affecting cell motility of human mesothelioma cells. Cell Proliferation , in press 
Nicoletti R, 2001. Produzione di un metabolita fungitossico da parte di un nuovo isolato di Penicillium pinophilum. Italian Patent n. 01308189, issued by the Central Patent Office of the Ministry for Productive Activities on 7 December 2001 
Nicoletti R, 2001. Produzione di un metabolita fungitossico da parte di un nuovo isolato di Penicillium pinophilum. Italian Patent n. 01308189, issued by the Central Patent Office of the Ministry for Productive Activities on 7 December 2001 
Characterization
Molecular and/or biochemical characterization secondary metabolite (3-O-methylfunicone, 2-methyl,4-hydroxybenzoic acid)